Possible new trigger mechanism of colon and rectal cancer
A possible new trigger mechanism of colon and rectal cancer may have been found by a research team led by a Zhang Lingqiang of the Radiation and Radiology Meadical Research Institute of the Military Medical Sciences Academy in China.
The research concluded that the ubiquitin-protein ligase SMURF 1 may be a causal factor in the promotion of colon and rectal cancers’ occurrence and growth.
Academician of the Chinese Academy of Sciences He Fuchu said that the result indicates that this is different from the zinc lipoid ligase.
The research analyzed samples from 336 colon and rectal cancer patients and found that modification of the enzymic system of the ubiquitin-protein pathway was highly expressive in colon and rectal cancers, and this modification was assisted by the SMURF 1 to promote the reduction and dissolution of anti-cancer suppressive proteins. This has provided an explanation as to why the ubiquitin-protein ligase SMURF 1 has the ability to promote cancer.