Alport syndrome is hereditary nephritis with end stage kidney disease.
Among 39 four generation family members of a Shenzhen family, 29 have kidney disease: 7 have died, 12 have been diagnosed as having kidney disease, 8 have been found to have latent Alport syndrome genes, and 2 have diabetes caused by Alport syndrome.
The mother-in-law is the first generation. She gave birth to the second generation of 2 sons and 5 daughters. They gave birth to the third generation of 5 sons and 6 daughters. And they gave birth to the fourth generation of 13 sons and 7 daughters. The mother of two of these daughters died of kidney disease on December 4, 2015, and the two daughters have been diagnosed as having Alport syndrome.