Interaction between FOXP2 and MEF2C found to affect autistic language development
It is known that the FOXP2 or Forkhead Box Protein 2 is required for proper development of language and speech.
Professor Liu fu-ching at the Neurosciences Research Institute at Yangming University used ultrasound to study the interaction between the FOXP2 and the MEF2C or Myocyte Specific Enhancer Factor 2C, a transcription factor in the family of factors including three isoforms from phosphorylation, sumoylation and acetylation.
It is found that mutation in the MEF2C damages the development of the cortical-subcortical feedback and affects the FOXP2C gene, leading to autistic language development. It is also found that interaction between the FOX2 and the MEF2C adjusts and controls the cortical-subcortical feedback and the development of intelligent action.